Macromolecular Structures is the course for students of Nanotechnology Engineering at the Faculty of Engineering, Sapienza University of Rome.

Objective of this course is to learn the basis of biology and biochemistry.

Program of the Course: The cell, Biomolecules, The water, Carbohydrates, Lipids, Proteins: amino acids and the peptide bond, Proteins: Primary, secondary, tertiary, quaternary structure.  Protein function: Actin, myosin, and the muscle contraction. Protein function: myoglobin and hemoglobin. Protein function: Antibodies and the immune system. Protein function: Carrier, channels and receptors. Protein function: Enzymes. Genomes and evolution. The structure of DNA, genes e chromosomes, RNA: structure and function, DNA, duplication and transcription, Translation and gene expression. 

Books useful for studying:
- Lehninger Principles of Biochemistry David L. Nelson and Michael M. Cox;
- Brown and Foote, Organic Chemistry,Edises;


- Chemical foundation of biomolecules: basis of organic chemistry;
- The cell structure and the living organism
- the cellular respiration: Glycolysis, Krebs cycle, oxidative phosphorylation and ATP synthesis;
- Carbohydrates: monosaccharide, disaccharides and polysaccharides;
- Lipids: fatty acids and triglycerides. Phospholipids, glycolipids, sphingolipids and sterols.
- Proteins: amino acid structure and peptide bond (protein primary structure);
- Folding of the proteins: secondary, tertiary, quaternary structure;
- DNA and RNA: structure;
- Oxygen binding proteins: myoglobin and hemoglobin;
- Immunoglobulin and immune system;
- Actin and Myosin: muscle contraction;
- Enzymes: kinetics, mechanism and inhibitors
- Cell membrane: carrier, channel and receptor (structure and function);
- DNA Metabolism: DNA Replication;
- RNA Metabolism: Transcription;
- Protein Metabolism: Translation;
- Gene expression and evolution;
- Regulation of gene expression;

Slides used during the Lessons:

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